Main genetic differences in high-grade gliomas may present different MR imaging and MR spectroscopy correlates

ConclusionsOur results suggest that IDH1-wt tumours are more necrotic than IDH1-mut. And that the presence of an infiltrative pattern in HGG is associated with loss of p53 expression, Ki-67 index, and Glx levels. Finally, tumour choline levels could be used as a predictive factor in survival in addition to the IDH1 status to provide a more accurate prediction of survival in HGG patients.Key Points•IDH1-wt tumours present higher levels of mobile lipids than IDH1-mut.• Mutated ATRX tumours exhibit higher levels of glutamate and glutamine.• Loss of p53 expression, Ki-67 expression, and glutamate and glutamine levels may contribute to the presence of an infiltrative pattern in HGG.
Source: European Radiology - Category: Radiology Source Type: research