Contrast-enhancement in the wall of a cerebral fusiform aneurysm in neuroborreliosis at 7  T MRI

neuroborreliosis-related CNS vasculitis is believed to be a manifestation of Lyme disease [1,2]. We here report the case of a patient, diagnosed with neuroborreliosis and a fusiform cerebral aneurysm. We made use of 7 Tesla magnetic resonance imaging (MRI), in order to better visualize the aneurysm and discriminate between a congenital and an infectious malformation. The ultra-high resolution imaging permitted the representation of the vessel wall and showed accumulation of contrast medium, which, along with localization and form of the malformation, reinforced the suspicion of an infectious cause of the aneurysm.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Letter to the Editor Source Type: research

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CONCLUSION: Lyme-associated uveitis appears varied. Hyalitis and involvement of the posterior segment and retinal vasculitis seem to be rather frequent. Its prognosis is mainly good, even if inflammation can be resistant or recurring. PMID: 31238716 [PubMed - as supplied by publisher]
Source: European Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Eur J Ophthalmol Source Type: research
Larissa A. Martins1, Camila D. Malossi1†, Maria F. B. de M. Galletti1†, José M. Ribeiro2, André Fujita3, Eliane Esteves4, Francisco B. Costa5, Marcelo B. Labruna5, Sirlei Daffre1 and Andréa C. Fogaça1* 1Departamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil 2Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD, United States 3Departamento de Ciência da Computação, Instituto de Matemática e Estatística,...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Conclusions OCB are important biomarkers that can support MRI diagnostics and help to avoid false-positive MS diagnoses. Therefore, the revised McDonalds criteria have increased the importance of the OCB. New biomarkers such as AQP4 have now established themselves in clinical practice, and others such as Anti-MOG and NfL are about to enter clinical routine. An important focus in the search for new biomarkers is the monitoring of therapy efficacy and the prediction of severe side effects. Many other CSF molecules such as CHI3L1, IL-6, or CXCL13 show potential as markers for clinical practice, but further research is nee...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
This article can educate those engaged in imaging of the nervous system and serve as a comprehensive tool in clinical cases.Key Points•Diagnostic criteria for LNB emphasise exclusion of an alternative cause to the clinical symptoms.•MRI makes a crucial contribution in the diagnosis and follow-up of LNB.•MRI may have normal findings, or show neuritis, meningitis, myelitis, encephalitis or vasculitis.•White matter lesions are not a prominent feature of LNB.
Source: Insights into Imaging - Category: Radiology Source Type: research
Patient Presentation A 9-year-old male came to clinic with a 1 month history of painful joint swelling. One month ago he started having right ankle pain that was intermittent but consistent. One day ago his right wrist, right ankle and bilateral knees had some swelling but no erythema or warmth. He says that he has pain in them when he moves but not when he is resting and he denies any joint stiffness or gelling. He also had 1-2 days of multiple red skin lesions on his extremities and trunk, not overlying the affected joints. The skin lesions do not come and go and do not itch. They are mainly discrete circular lesions wi...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
CONCLUSIONS: Lyme Neuroborreliosis accounts for a small proportion of paediatric stroke even in an endemic country. The strong predilection towards posterior cerebral circulation with clinical occurrence of brainstem signs associated with meningeal symptoms and CSF lymphocytosis are suggestive features that should rapidly point to the diagnosis. This can confirmed by appropriate serological testing in the serum and CSF. Clinicians must be aware of this rare neurological complication of Lyme disease that demands specific antibiotic treatment. PMID: 29208342 [PubMed - as supplied by publisher]
Source: European Journal of Paediatric Neurology - Category: Neurology Authors: Tags: Eur J Paediatr Neurol Source Type: research
Publication date: 2017 Source:Handbook of Clinical Neurology, Volume 145 Author(s): Istvan Katona, Joachim Weis This chapter reviews the diseases of the peripheral nerves from a neuropathologic point of view, with a special focus on specific morphologic changes, and includes a summary of the histopathologic methods available for their diagnosis. As the rate of obesity and the prevalence of type 2 diabetes increase, diabetic neuropathy is the most common cause of peripheral neuropathy. Many systemic disorders with metabolic origin, like amyloidosis, hepatic failure, vitamin deficiencies, uremia, lipid metabolism disorders,...
Source: Handbook of Clinical Neurology - Category: Neurology Source Type: research
Authors: Silverman ED Abstract The 72nd Annual Meeting of The Canadian Rheumatology Association (CRA) was held at The Westin Ottawa, Ottawa, Ontario, Canada, February 8-11, 2017. The program consisted of presentations covering original research, symposia, awards, and lectures. Highlights of the meeting include the following 2017 award winners: Dr. Vinod Chandran, Young Investigator; Dr. Jacques P. Brown, Distinguished Investigator; Dr. David Robinson, Teacher-Educator; Dr. Michel Zummer, Distinguished Rheumatologist; Ms. Rebecca Gole, Best Abstract on SLE Research by a Trainee - Ian Watson Award; Ms. Bailey Russell...
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research
Conclusions:Antibiotic treatment for S. pneumoniae meningitis correlated with improvement in clinical status and TCD hemodynamics. Serial TCDs may be a potentially useful strategy in the management of bacterial meningitis.Disclosure: Dr. Idris has nothing to disclose. Dr. Tai has nothing to disclose. Dr. Tan has nothing to disclose. Dr. Tan has nothing to disclose.
Source: Neurology - Category: Neurology Authors: Tags: Autoimmunity with Infection, Syphilis, Lyme, Tuberculosis, and other Bacteria Source Type: research
Lyme neuroborreliosis (LNB) is a disease of the nervous system caused by the spirochete Borrelia burgdorferi sensu lato genospecies, which is transmitted by the bite of infected ticks. Approximately 15% of patients with Lyme borreliosis develop neurological manifestations; most frequently meningitis, cranial neuritis or polyradiculitis [1]. Ischemic stroke due to cerebral vasculitis is rarely (
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Letter to the Editor Source Type: research
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