Reducing Vasopressor Exposure in Patients With Vasodilatory Hypotension

To the Editor A clinical trial by Dr Lamontagne and colleagues showed that reducing exposure to vasopressors through a lower mean arterial pressure (MAP) target during resuscitation in older patients with vasodilatory hypotension decreased 90-day mortality, although it did not reach statistical significance. Three large randomized clinical trials also showed that early goal-directed therapy did not improve outcomes in patients with septic shock.
Source: JAMA - Category: General Medicine Source Type: research