Cancers, Vol. 12, Pages 2482: Counteracting Chemoresistance with Metformin in Breast Cancers: Targeting Cancer Stem Cells
Cancers, Vol. 12, Pages 2482: Counteracting Chemoresistance with Metformin in Breast Cancers: Targeting Cancer Stem Cells
Cancers doi: 10.3390/cancers12092482
Authors:
Samuel
Varghese
Koklesová
Líšková
Kubatka
Büsselberg
Despite the leaps and bounds in achieving success in the management and treatment of breast cancers through surgery, chemotherapy, and radiotherapy, breast cancer remains the most frequently occurring cancer in women and the most common cause of cancer-related deaths among women. Systemic therapeutic approaches, such as chemotherapy, although beneficial in treating and curing breast cancer subjects with localized breast tumors, tend to fail in metastatic cases of the disease due to (a) an acquired resistance to the chemotherapeutic drug and (b) the development of intrinsic resistance to therapy. The existence of cancer stem cells (CSCs) plays a crucial role in both acquired and intrinsic chemoresistance. CSCs are less abundant than terminally differentiated cancer cells and confer chemoresistance through a unique altered metabolism and capability to evade the immune response system. Furthermore, CSCs possess active DNA repair systems, transporters that support multidrug resistance (MDR), advanced detoxification processes, and the ability to self-renew and differentiate into tumor progenitor cells, thereby supporting cancer invasion, metastasis, and recurrence/relapse. Hence, current research is focusing on targeting CSCs to overco...
Source: Cancers - Category: Cancer & Oncology Authors: Samuel Varghese Koklesov á L íšková Kubatka B üsselberg Tags: Review Source Type: research
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