Increased lipopolysaccharide content is positively correlated with glucocorticoid receptor ‐beta expression in chronic rhinosinusitis with nasal polyps

ConclusionsPersistent LPS in CRSwNP can lead to unresolved mucosal inflammation, eventually leading to tissue remodeling and the development of CRSwNP. Our findings suggest that increased LPS content and possible resistance to glucocorticoids may be one of the important pathogenic mechanisms of G− bacteria in CRSwNP.

Source: Immunity, Inflammation and Disease - August 31, 2020 Category: Allergy & Immunology Authors: Shui ‐Bin Wang, Shi‐Ming Chen, Ke‐Sheng Zhu, Bin Zhou, Long Chen, Xiao‐Yan Zou Tags: ORIGINAL RESEARCH Source Type: research