Structures and biological evaluation of phenylpropanoid derivatives from Dendrobium Sonia.

Structures and biological evaluation of phenylpropanoid derivatives from Dendrobium Sonia.
Nat Prod Res. 2020 Aug 31;:1-5
Authors: Cai BX, Song LX, Hu HJ, Han ZZ, Zhou Y, Wang ZT, Yang L
Abstract
Two new phenylpropanoid derivatives (1-2), together with eight known compounds (3-10) were isolated from the stems of Dendrobium sonia. The structures of these compounds were elucidated on the basis of spectroscopic analyses, including HRESIMS, 1 D and 2 D NMR experiments. All of the isolated compounds were tested for their Nitric Oxide (NO) Inhibitory Activities. The results of bioactive screening showed that compounds 2, 8, 9 and 10 exerted inhibitory effects on NO production with IC50 values in the range of 26.3 to 31.6 μM. Compound 8 and 9 exhibited stronger anti-inflammatory activities with IC50 values 26.3 and 27.7 μM, comparable to that of the positive control.
PMID: 32865021 [PubMed - as supplied by publisher]

Source: Natural Product Research - August 30, 2020 Category: Biochemistry Authors: Cai BX, Song LX, Hu HJ, Han ZZ, Zhou Y, Wang ZT, Yang L Tags: Nat Prod Res Source Type: research