Cerebrospinal fluid metabolomic profiles associated with fatigue during treatment for pediatric acute lymphoblastic leukemia

Cancer-related fatigue (CRF) is one of the most distressing and persistent symptoms reported during pediatric acute lymphoblastic leukemia (ALL) therapy; however, information on the pathways underlying CRF severity is limited. Therefore, we conducted global metabolomics profiling of cerebrospinal fluid (CSF) samples to provide insight into the underlying mechanisms of CRF.

Source: Journal of Pain and Symptom Management - August 31, 2020 Category: Palliative Care Authors: Austin L. Brown, Pagna Sok, Olga Taylor, John P. Woodhouse, M. Brooke Bernhardt, Kimberly P. Raghubar, Lisa S. Kahalley, Philip J. Lupo, Marilyn J. Hockenberry, Michael E. Scheurer Source Type: research