An Acidic Environment Induces APOL1-Associated Mitochondrial Fragmentation.

CONCLUSION: Acidic pH facilitates early mitochondrial dysfunction induced by APOL1 G1 and G2 KRVs in HEK293 cells. We propose that the acidic kidney interstitium may play a role in APOL1-mediated mitochondrial pathophysiology and nephropathy.
PMID: 32866949 [PubMed - as supplied by publisher]

Source: American Journal of Nephrology - August 30, 2020 Category: Urology & Nephrology Authors: Li D, Snipes JA, Murea M, Molina AJA, Divers J, Freedman BI, Ma L, Petrovic S Tags: Am J Nephrol Source Type: research