Antiepileptic overdose - Murty S.

Antiepileptics include various groups of drugs that have different mechanisms of actions and adverse effects. They are often also used to treat other disorders such as psychosis, chronic pain, and migraine. The most common drugs implicated in overdose incl...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Home and Consumer Product Safety Source Type: news

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(CNN) — Cannabidiol, the non-psychoactive ingredient in hemp and marijuana, could treat opioid addiction, a new study says. Given to patients with heroin addiction, cannabidiol, also known as CBD, reduced their cravings for the illicit drug as well as their levels of anxiety. “The intense craving is what drives the drug use,” said Yasmin Hurd, the lead researcher on the study and director of the Addiction Institute of Mount Sinai. “If we can have the medications that can dampen that [craving], that can greatly reduce the chance of relapse and overdose risk.” CBD: What Is It And Why Do People U...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CBD CNN Source Type: news
CONCLUSIONS: Fremanezumab is a generally safe and well-tolerated preventive therapy for migraine in adults. PMID: 30977520 [PubMed - as supplied by publisher]
Source: Headache - Category: Neurology Authors: Tags: Headache Source Type: research
Ryan R. Kelly1,2†, Lindsay T. McDonald1,2†, Nathaniel R. Jensen1,2, Sara J. Sidles1,2 and Amanda C. LaRue1,2* 1Research Services, Ralph H. Johnson VA Medical Center, Charleston, SC, United States 2Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States The significant biochemical and physiological effects of psychological stress are beginning to be recognized as exacerbating common diseases, including osteoporosis. This review discusses the current evidence for psychological stress-associated mental health disorders as risk factors for os...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
How Bad Is Fentanyl? Fentanyl is an extremely dangerous synthetic opioid. Unlike some other opioids that occur naturally, it is man-made for the purpose of helping aid people suffering from extreme pain. It can be administered for recovery after surgery, during cancer treatments or for recovery after a painful injury. The Drug Enforcement Administration (DEA) classifies fentanyl as a Schedule II controlled substance. This means that it is legal for medical use, however, it has an extremely high potential for abuse and addiction. Understanding Fentanyl Significantly stronger than morphine or oxycodone, Fentanyl can be fatal...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Addiction to Pharmaceuticals Drug Rehab Information Drug Treatment Heroin Painkiller Substance Abuse Synthetic fentanyl prescription drug abuse prescription drug addiction prescription drug detox prescription drug use p Source Type: blogs
AbstractPurpose of ReviewGiven that the primary cause of overdose death in the USA is related to prescribed opioids, one potential strategy to improve awareness and decrease morbidity and/or mortality could include improved labeling. Specific patient populations which significantly struggle with adverse outcomes related to opioid abuse are seen in palliative care, chronic pain, and acute pain treatment settings.Recent FindingsAn unexplored option for improving the healthcare quality and safety for patients currently prescribed opioids would be to require pharmaceutical companies to provide a morphine milligram equivalent (...
Source: Current Pain and Headache Reports - Category: Neurology Source Type: research
Conclusion. Modafinil is a central nervous system stimulant with well-established effectiveness in the treatment of narcolepsy and shift-work sleep disorder. There is conflicting evidence about the benefits of modafinil in the treatment of fatigue and EDS secondary to TBI. One randomized, controlled study states that modafinil does not significantly improve patient wakefulness, while another concludes that modafinil corrects EDS but not fatigue. An observational study provides evidence that modafinil increases alertness in fatigued patients with past medical history of brainstem diencephalic stroke or multiple scleros...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue Review excessive daytime sleep fatigue head injury modafinil stroke TBI traumatic brain injury Source Type: research
Abstract Opioid misuse, including the use of heroin and the overprescribing, misuse, and diversion of opioid pain medications, has reached epidemic proportions in the United States. As a result, there has been a dramatic increase in opioid use disorder and associated overdoses and deaths. Addiction is a chronic brain disease with a genetic component that affects motivation, inhibition, and cognition. Patient characteristics associated with successful buprenorphine maintenance treatment include stable or controlled medical or psychiatric comorbidities and a safe, substance-free environment. As a partial opioid agon...
Source: American Family Physician - Category: Primary Care Authors: Tags: Am Fam Physician Source Type: research
AbstractPurpose of ReviewThe prevalence of chronic pain and prescription opioid abuse has resulted in epidemic problems for patients and clinicians. The consequences are taking a heavy toll on patients, physicians, and society. Specific to radiology, a significant need exists for best practice assessment and treatment approaches for pain management, as patients with chronic pain often undergo radiological tests of unclear clinical relevance.Recent FindingsThe USA is amid an opioid-prescribing epidemic and resultant overdose public health emergency. A variety of reasons, which are examined in this manuscript, have contribut...
Source: Current Pain and Headache Reports - Category: Neurology Source Type: research
AbstractPurpose of ReviewThe opioid crisis most likely is the most profound public health crisis our nation has faced. In 2015 alone, 52,000 people died of drug overdoses, with over 30,000 of those people dying from opioid drugs. A recent community forum led by the Cleveland Clinic contrasted this yearly death rate with the loss of 58,000 American lives in 4  years of the Vietnam War. The present review describes the origins of this opioid epidemic and provides context for our present circumstances.Recent FindingsAlarmingly, the overwhelming majority of opioid abusers begin their addiction with prescription medication...
Source: Current Pain and Headache Reports - Category: Neurology Source Type: research
ConclusionAdditional research on the relative safety and efficacy of non-opioid approaches to emergency department analgesia is needed. Despite a limited research base, it is likely that non-opioid analgesic modalities will be employed with increasing frequency. A new generation of emergency physicians is seeking additional training in pain medicine and increasing dialogue between emergency medicine and pain medicine researchers, educators and clinicians could contribute to better management of emergency department pain.
Source: Pain and Therapy - Category: Anesthesiology Source Type: research
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