MiR-302a-3p aggravates myocardial ischemia-reperfusion injury by suppressing mitophagy via targeting FOXO3.

CONCLUSION: Our study suggested that inhibition of miR-302a-3p promoted mitochondrial autophagy and inhibited oxidative stress by targeting FOXO3 to suppress myocardial apoptosis, representing a potential target for MIRI treatment.
PMID: 32866521 [PubMed - as supplied by publisher]

Source: Experimental and Molecular Pathology - August 27, 2020 Category: Pathology Authors: Lv W, Jiang J, Li Y, Fu L, Meng F, Li J Tags: Exp Mol Pathol Source Type: research