Cell Cycle Dysregulation in Mantle Cell Lymphoma: Genomics and Therapy.

This article reviews aberrations of cell cycle genes in MCL cells and clinical trials of CDK4/6 inhibitors for MCL. Integrative longitudinal functional genomics is discussed as a strategy to discover genomic drivers for resistance in cancer cells and cancer-immune interactions that potentially contribute to the clinical response to palbociclib combination therapy in MCL. PMID: 32861279 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/32861279?dopt=Abstract

Source: The Medical Clinics of North America - September 1, 2020 Category: General Medicine Authors: Wang K, Huang X, Di Liberto M, Chen-Kiang S Tags: Hematol Oncol Clin North Am Source Type: research