Burkitt Lymphoma - Subtypes, Pathogenesis, and Treatment Strategies.

Burkitt Lymphoma - Subtypes, Pathogenesis, and Treatment Strategies. Clin Lymphoma Myeloma Leuk. 2020 Sep;20 Suppl 1:S37-S38 Authors: Noy A Abstract Burkitt's lymphoma (BL) is a rare and highly aggressive Non-Hodgkin lymphoma (NHL) with a germinal center phenotype, a nearly universal myc oncogene translocation to an enhancer element and a proliferation index greater than 95%.1 Bcl-2 is not expressed as opposed to double-hit or triple-hit lymphoma. Genetic mutations and aberrancy involving the phosphatidylcholine 3-kinase and cyclin-dependent kinase pathways are also involved.2-5 Rarely patients present with stage I disease and others are considered as high risk if greater than stage I or with elevated LDH or masses greater than 10 cm. PMID: 32862862 [PubMed - in process]
Source: Clinical Lymphoma and Myeloma - Category: Cancer & Oncology Authors: Tags: Clin Lymphoma Myeloma Leuk Source Type: research