Cancers, Vol. 12, Pages 2467: Second-Generation Antiandrogen Therapy Radiosensitizes Prostate Cancer Regardless of Castration State Through Inhibition of DNA Double Strand Break Repair

Conclusion: Together, these data show that second-generation antiandrogens can enhance radiosensitivity in PCa through DSB repair inhibition, regardless of their hormonal status. Translated into clinical practice, our results may help to find additional strategies to improve the effectiveness of RT in localized PCa, paving the way for a clinical trial.

Source: Cancers - August 30, 2020 Category: Cancer & Oncology Authors: Mohamed E. Elsesy Su Jung Oh-Hohenhorst Anastassia L öser Christoph Oing Sally Mutiara Sabrina K öcher Stefanie Meien Alexandra Zielinski Susanne Burdak-Rothkamm Derya Tilki Hartwig Huland Rudolf Schwarz Cordula Petersen Carsten Bokemeyer Kai Rothkamm W Tags: Article Source Type: research