Betulinic acid inhibits cell proliferation and migration in gastric cancer by targeting the NF- κB/VASP pathway.

In conclusion, these results suggest that BA could inhibit the expression of VASP by negatively regulating NF-κB, thereby inhibiting the proliferation and migration of the GC cells. Our study provides a theoretical basis for exploring the molecular mechanism underlying BA-induced inhibition of proliferation and migration in GC cells.
PMID: 32860808 [PubMed - as supplied by publisher]

Source: European Journal of Pharmacology - August 25, 2020 Category: Drugs & Pharmacology Authors: Chen X, Yuan XN, Zhang Z, Gong PJ, Yin WN, Jiang Q, Xu J, Xu XL, Gao Y, Chen WL, Chen FF, Tian YH, Wei L, Zhang JW Tags: Eur J Pharmacol Source Type: research