Forced expression of miR-143 and -145 in cardiomyocytes induces cardiomyopathy with a reductive redox shift.

Conclusions: Overexpression of miR-143 and miR-145 leads to a unique dilated cardiomyopathy phenotype with a reductive redox shift despite marked downregulation of HK2 expression. Reductive stress may be involved in a wider range of cardiomyopathies than previously thought. PMID: 32855642 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/32855642?dopt=Abstract

Source: Cellular and Molecular Biology Letters - August 30, 2020 Category: Biochemistry Authors: Ogawa K, Noda A, Ueda J, Ogata T, Matsuyama R, Nishizawa Y, Qiao S, Iwata S, Ito M, Fujihara Y, Ichihara M, Adachi K, Takaoka Y, Iwamoto T Tags: Cell Mol Biol Lett Source Type: research