The Changes of Serum Zinc, Copper and Selenium Levels in Epileptic Patients ：A Systematic Review and Meta-Analysis.

In this study, we performed a meta-analysis of the changes in serum Zn, Cu and Se levels in human samples of healthy controls, epileptic patients and patients treated with VPA. Twenty-two published analyzable studies were selected by searching the databases of PubMed, China National Knowledge Infrastructure (CNKI), Google Scholar, Web of Science, EMBASE, WANFANG and Vip. EXPERT OPINION: This meta-analysis showed that serum Se levels were significantly lower in epileptic patients compared to healthy controls. Additionally, serum Zn levels in epileptic patients with VPA were significantly lower than those before the treatment. It is essential to monitor serum Se levels in epileptic patients and serum Zn levels in patients treated with VPA. PMID: 32856976 [PubMed - as supplied by publisher]
Source: Expert Review of Clinical Pharmacology - Category: Drugs & Pharmacology Tags: Expert Rev Clin Pharmacol Source Type: research