United States Pulmonary Hypertension Scientific Registry (USPHSR): Baseline Characteristics.

United States Pulmonary Hypertension Scientific Registry (USPHSR): Baseline Characteristics. Chest. 2020 Aug 25;: Authors: Badlam JB, Badesch DB, Austin ED, Benza RL, Chung WK, Farber HW, Feldkircher K, Frost AE, Poms AD, Lutz KA, Pauciulo MW, Yu C, Nichols WC, Elliott CG, Simms R, Fortin T, Safdar Z, Burger CD, Frantz RP, Hill NS, Airhart S, Elwing J, Marc SR, White J, Robbins IM, Chakinala MM Abstract BACKGROUND: The treatment, genotyping and phenotyping of patients with WHO Group 1 pulmonary arterial hypertension (PAH) has evolved dramatically in the last decade. RESEARCH QUESTION: The USPHSR was established as the first US PAH patient registry to investigate genetic information, reproductive histories, and environmental exposure data in a contemporary patient population. STUDY DESIGN: and Methods: Investigators at 15 US centers enrolled consecutively screened adults diagnosed with Group 1 PAH who had enrolled in the National Biological Sample and Data Repository for PAH (PAH Biobank) within 5 years of a cardiac catheterization demonstrating qualifying hemodynamic criteria. Exposure and reproductive histories were collected using a structured interview and questionnaire. The PAH Biobank provided genetic data. RESULTS: Between 2015 and 2018, 499 of 979 eligible patients with clinical diagnoses of idiopathic (IPAH) or familial PAH (N=240, 48%), associated PAH (APAH, N=256, 51%), or pulmonary veno-occlusive di...
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research