Radiation Disrupts the Protective Function of the Spinal Meninges in a Mouse Model of Tumor-induced Spinal Cord Compression.

CONCLUSIONS: Intradural tumor invasion and disruptions of the dural microstructure were observed in the meninges of mice after irradiation, indicating radiation-induced disruption of the meningeal barrier.
CLINICAL RELEVANCE: We conclude that in this form of delivery, radiation is associated with disruption of the dural meningeal barrier, indicating a need to consider methods to avoid or limit Postradiation tumor relapse and spinal cord compression when treating spinal metastases so that patients do not experience intradural tumor invasion. Surgeons should be aware of the potential for intradural tumor invasion when they perform post-irradiation spinal surgery to minimize the risks for intraoperative dural injury and spinal cord injury. Further research in patients with irradiated spinal metastases is necessary to confirm that the same findings are observed in humans and to seek irradiation methods that prevent or minimize the disruption of meningeal barrier function.
PMID: 32858719 [PubMed - as supplied by publisher]

Source: Clinical Orthopaedics and Related Research - August 25, 2020 Category: Orthopaedics Authors: Shimizu T, Demura S, Kato S, Shinmura K, Yokogawa N, Yonezawa N, Oku N, Kitagawa R, Handa M, Annen R, Nojima T, Murakami H, Tsuchiya H Tags: Clin Orthop Relat Res Source Type: research