Epithelial Barrier Dysfunction Induced by Hypoxia in Respiratory System.

Epithelial Barrier Dysfunction Induced by Hypoxia in Respiratory System. Curr Pharm Des. 2020 Aug 25;: Authors: Hou Y, Ding Y, Liu Y, Xie X, Cui Y, Nie H Abstract Steady and continuous supply of oxygen is important for humans, since an excess or deficiency in oxygen levels may result in the death of cells, tissue, or the organism. As a mechanical barrier against pathogens, the respiratory epithelium is always exposed to hypoxia in some detrimental external environment and/or pathologic state. The barrier function is accordingly impaired as a result of disrupted cell composition ratio, ion transport, and tight junctions in a hypoxia-inducible factor dependent or independent way. Hypoxia has been identified as an element of the primary or secondary pathogenic factors of many respiratory diseases, but the relationship between hypoxia and epithelial barrier dysfunction is not fully understood. Thus we summarized recent researches on epithelial barrier dysfunction induced by hypoxia in respiratory system, aiming to explore the possible therapeutic targets in hypoxia related respiratory system diseases. PMID: 32842936 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research