Cytogenetic and Molecular Study of an Adult Sclerosing Rhabdomyosarcoma of the Extremity: MYOD1-mutation and Clonal Evolution

Conclusion: To our knowledge, this is the first adult MYOD1-mutant sclerosing rhabdomyosarcoma studied cytogenetically. The only other reported sclerosing rhabdomyosarcoma with MYOD1 mutation and abnormal karyotype was pediatric. Since these tumors are highly aggressive, further studies unravelling their cytogenetic and molecular characteristics are warranted.

Source: Cancer Genomics and Proteomics - August 27, 2020 Category: Cancer & Oncology Authors: GORUNOVA, L., BJERKEHAGEN, B., MICCI, F., HEIM, S., PANAGOPOULOS, I. Tags: Experimental Studies Source Type: research