Cancer-associated fibroblasts promote cell proliferation and invasion via paracrine Wnt/IL1 β signaling pathway in human bladder cancer.

In conclusion, our data revealed a novel mechanism that CAFs promote cell proliferation and invasion of human BC cells through Wnt/IL1β signaling feedback. Inhibition of the Wnt signaling pathway may provide a promising target to block the interaction between CAF and bladder cancer cells.
PMID: 32853019 [PubMed - as supplied by publisher]

Source: Neoplasma - August 27, 2020 Category: Cancer & Oncology Authors: Yang F, Guo Z, He C, Qing L, Wang H, Wu J, Lu X Tags: Neoplasma Source Type: research