Primary central nervous system lymphoma after heart transplantation: A case report and literature review

This report described a 53-year-old male who was diagnosed as PCNSL 17 months after heart transplantation. Diagnoses: The patient was admitted to the local hospital presenting with dizziness, headache, and reduced left-sided power and sensation for 1 week. He had a medical history of heart transplantation because of the dilated cardiomyopathy 17 months ago and had a 17-month history of immunosuppressive therapy with tacrolimus. A computed tomography scan of the brain revealed a bulky mass in the right temporal lobe. The emergency intracranial mass resection and cerebral decompression were performed in our hospital. The histopathology of the brain lesions showed diffuse large B-cell lymphoma. A further 18FDG positron emission tomography-computed tomography scan of the whole body showed no significantly increased metabolic activity in other regions. The final diagnosis of this patient was PCNSL after heart transplantation. Interventions: Given the poor health condition, with the patient's consent, the whole brain radiotherapy was performed with supportive care. Outcomes: The disease deteriorated rapidly during the period of receiving radiotherapy, and he died within 2 months from the diagnosis. Lessons: PCNSL after heart transplantation is an extremely rare phenomenon with extremely poor prognosis. We should pay close attention to the heart recipients, especially when the patients present with neurological symptoms and signs. The available treatment options for PCNS...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research