Synthesis of heterofunctional polyester dendrimers with internal and external functionalities as versatile multipurpose platforms.

Synthesis of heterofunctional polyester dendrimers with internal and external functionalities as versatile multipurpose platforms. Biomacromolecules. 2020 Aug 27;: Authors: García-Gallego S, Stenström P, Mesa-Antunez P, Zhang Y, Malkoch M Abstract Heterofunctional dendrimers with internal and external representation of functionalities are considered as the ultimate dendritic frameworks. This is reflected by their unprecedented scaffolding, such as precise control over structure, molecular weight, number and location of different cargo across the whole dendritic skeleton. Consequently, these dendrimers with multipurpose character are the pinnacle of precision polymers and thereof are highly attractive by the scientific community as they can find use in a great number of cutting-edge applications, especially as discrete unimolecular carriers for therapeutic exploitation. Unfortunately, most established dendrimer families display external functionalities but lack internal scaffolding ability, which lead to inherent limitation for their full potential use as precision carriers. Consequently, we here embark on a novel synthetic strategy facilitating the introduction of internal functionalization of established dendrimers. As a Proof-of-Concept, a new class of internally and externally functionalized multipurpose dendrimers based on the established 2,2-bis(methylol)propionic acid (bis-MPA) were successfully accomplished by the elegant an...
Source: Biomacromolecules - Category: Biochemistry Authors: Tags: Biomacromolecules Source Type: research