Association of fractalkine with functional severity of heart failure and impact on clopidogrel efficacy in patients with ischemic heart disease

Patients with heart failure (HF) display elevated levels of soluble fractalkine, a chemokine involved in inflammation processes, atherosclerosis and platelet activation. Further, fractalkine has been associated with reduced pharmacodynamic (PD) responsiveness to clopidogrel. The aim of this study was to investigate the association of fractalkine with the severity of HF and its impact on platelet activation and clopidogrel response in patients with coronary artery disease (CAD) with and without HF.

Source: Thrombosis Research - August 26, 2020 Category: Hematology Authors: Ana Lucrecia Marcano, Leslie Marisol Lugo, Adri án Besteiro, Josep Gomez-Lara, Gerard Roura, Lara Fuentes, Montserrat Gracida, Luis Teruel, Rafael Romaguera, Silvia Gabriela Sosa, Ángel Cequier, Joan A. Gómez-Hospital, Josep Comin-Colet, José Luis Fer Tags: Full Length Article Source Type: research