A new depsidone derivative from mangrove endophytic fungus Aspergillus sp. GXNU-A9.

A new depsidone derivative from mangrove endophytic fungus Aspergillus sp. GXNU-A9.
Nat Prod Res. 2020 Aug 27;:1-5
Authors: Hao L, Zhou D, Qin X, Zhang W, Yang R, Li J, Huang X
Abstract
A new tetracyclic depsidone derivative, guanxidone A (1), together with three known metabolites 2-4, was isolated from the mangrove endophytic fungus Aspergillus sp. GXNU-A9. The structure of compound 1 was established by HR-ESI-MS, 1 D and 2 D NMR data, as well as by comparison with literature data. Compounds 1-4 were evaluated for their anti-inflammatory effects on the production of the nitric oxide (NO), and compound 1 significantly reduced the production of NO in lipopolysaccharide (LPS)-stimulated cells with IC50 value of 8.22 µM.
PMID: 32851874 [PubMed - as supplied by publisher]

Source: Natural Product Research - August 26, 2020 Category: Biochemistry Authors: Hao L, Zhou D, Qin X, Zhang W, Yang R, Li J, Huang X Tags: Nat Prod Res Source Type: research