Biomedical application, Drug Delivery and Metabolic Pathway of Antiviral Nanotherapeutics for combating viral Pandemic: A Review.

Biomedical application, Drug Delivery and Metabolic Pathway of Antiviral Nanotherapeutics for combating viral Pandemic: A Review. Environ Res. 2020 Aug 23;:110119 Authors: Mukherjee S, Mazumder P, Joshi M, Joshi C, Dalvi SV, Kumar M Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a neoteric virus belonging to the beta coronavirus class has created a global health concern, responsible for an outbreak of severe acute respiratory illness, the COVID-19 pandemic. Infected hosts exhibit diverse clinical features, ranging from asymptomatic to severe symptoms in their genital organs, respiratory, digestive, and circulatory systems. Considering the high transmissibility (R0: ≤6.0) compared to Middle East respiratory syndrome coronavirus (MERS-CoV) and SARS-CoV, the quest for the clinical development of suitable antiviral nanotherapeutics (NTPs) is incessant. We are presenting a systematic review of the literature published between 2003 and 2020 to validate the hypothesis that the pharmacokinetics, collateral acute/chronic side effects of nano drugs and spike proteins arrangement of coronaviruses can revolutionize the therapeutic approach to cure COVID-19. Our aim is also to critically assess the slow release kinetics and specific target site chemical synthesis influenced competence of NTPs and nanotoxicity based antiviral actions, which are commonly exploited in the synthesis of modulated nanomedicines. The pathogenes...
Source: Environmental Research - Category: Environmental Health Authors: Tags: Environ Res Source Type: research