SOX10 is as specific as S100 protein in detecting metastases of melanoma in lymph nodes and is recommended for sentinel lymph node assessment

Sentinel lymph node (SLN) biopsy remains crucial for melanoma staging. The European Organisation for Research and Treatment of Cancer  Melanoma Group recommends performing immunohistochemical stainings for reproducible identification of melanoma metastases. S100 protein (pS100) is a commonly used melanocytic antigen because of its high sensitivity in spite of relatively low specificity. SRY-related HMG-box 10 protein (SOX10) is a transcription factor characterising neural crest-derived cells. It is uniformly expressed mostly in the nuclei of melanocytes, neural, and myoepithelial cells.

Source: European Journal of Cancer - August 7, 2020 Category: Cancer & Oncology Authors: Anna Szumera-Cie ćkiewicz, Francesca Bosisio, Paweł Teterycz, Asier Antoranz, Francesco Delogu, Senada Koljenović, Bart A. van de Wiel, Willeke Blokx, Léon C. van Kempen, Piotr Rutkowski, Alexander Christopher van Akkooi, Martin Cook, Daniela Massi, E Tags: Original Research Source Type: research