Single-nucleotide variants, tumour mutational burden and microsatellite instability in patients with metastatic colorectal cancer: Next-generation sequencing results of the FIRE-3 trial

Molecular biomarkers and primary tumour sidedness guide treatment decisions in metastatic colorectal cancer. Comprehensive molecular profiling aims to identify targetable alterations and measure tumour mutational burden (TMB) to enable precision oncology.

Source: European Journal of Cancer - August 14, 2020 Category: Cancer & Oncology Authors: Arndt Stahler, Sebastian Stintzing, Jobst C. von Einem, Christoph B. Westphalen, Kathrin Heinrich, Nicole Kr ämer, Marlies Michl, Dominik P. Modest, Ludwig Fischer von Weikersthal, Thomas Decker, Alexander Kiani, Tobias Heintges, Christoph Kahl, Frank Ku Tags: Original Research Source Type: research