Progress Toward Hepatitis B and Hepatitis C Elimination Using a Catalytic Funding Model - Tashkent, Uzbekistan, December 6, 2019-March 15, 2020

This report describes a funding program in Uzbekistan designed to identify and treat cases of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection at a lowered cost with the goal of meeting the World Health Organization's targets to eliminate HBC and HCV infection.
Source: CDC Morbidity and Mortality Weekly Report - Category: American Health Tags: Hepatitis B Hepatitis C MMWR Morbidity & Mortality Weekly Report Source Type: news

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Am J Transl Res. 2021 Aug 15;13(8):9771-9777. eCollection 2021.ABSTRACTOBJECT: Transfusion-transmitted infections threaten blood safety. The management of samples with weak reactivity is confusing. Our study aimed to investigate the utility of grey zone (GZ) testing in the screening of the hepatitis B virus (HBV), the hepatitis C virus (HCV), and the human immunodeficiency virus (HIV).METHODS: Chemiluminescence assays (CLA) were used for the blood screening. For each infectious marker, two CLA kits were used, but for each sample, only one kit was used for each infectious marker. An S/CO ≥ 8.0 was considered reactive, and an S/CO
Source: American Journal of Translational Research - Category: Research Authors: Source Type: research
Am J Clin Pathol. 2021 Sep 20:aqab125. doi: 10.1093/ajcp/aqab125. Online ahead of print.ABSTRACTOBJECTIVES: The pathologic differences between hepatocellular carcinoma (HCC) arising in noncirrhotic and cirrhotic livers have not been well studied.METHODS: We performed a retrospective analysis of 378 HCC cases (95 in noncirrhotic, 283 in cirrhotic livers) from pathology archives (2010-2017).RESULTS: Patients without cirrhosis were more likely to have hepatitis B (13.68% vs 2.83%, P
Source: American Journal of Clinical Pathology - Category: Pathology Authors: Source Type: research
We present a mathematical model based on machine learning methodologies to contribute to the design of screening programs in this population. We conducted a retrospective cross-sectional screening program of imported diseases in all immigrant patients who attended the Tropical Medicine Unit between January 2009 and December 2016. We designed a mathematical model based on machine learning methodologies to establish the set of most discriminatory prognostic variables to predict the onset of the: HIV infection, malaria, chronic hepatitis B and C, schistosomiasis, and Chagas in immigrant population. We analyzed 759 patients. H...
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Source Type: research
Am J Transl Res. 2021 Aug 15;13(8):9771-9777. eCollection 2021.ABSTRACTOBJECT: Transfusion-transmitted infections threaten blood safety. The management of samples with weak reactivity is confusing. Our study aimed to investigate the utility of grey zone (GZ) testing in the screening of the hepatitis B virus (HBV), the hepatitis C virus (HCV), and the human immunodeficiency virus (HIV).METHODS: Chemiluminescence assays (CLA) were used for the blood screening. For each infectious marker, two CLA kits were used, but for each sample, only one kit was used for each infectious marker. An S/CO ≥ 8.0 was considered reactive, and an S/CO
Source: American Journal of Translational Research - Category: Research Authors: Source Type: research
We present a mathematical model based on machine learning methodologies to contribute to the design of screening programs in this population. We conducted a retrospective cross-sectional screening program of imported diseases in all immigrant patients who attended the Tropical Medicine Unit between January 2009 and December 2016. We designed a mathematical model based on machine learning methodologies to establish the set of most discriminatory prognostic variables to predict the onset of the: HIV infection, malaria, chronic hepatitis B and C, schistosomiasis, and Chagas in immigrant population. We analyzed 759 patients. H...
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Source Type: research
Am J Transl Res. 2021 Aug 15;13(8):9771-9777. eCollection 2021.ABSTRACTOBJECT: Transfusion-transmitted infections threaten blood safety. The management of samples with weak reactivity is confusing. Our study aimed to investigate the utility of grey zone (GZ) testing in the screening of the hepatitis B virus (HBV), the hepatitis C virus (HCV), and the human immunodeficiency virus (HIV).METHODS: Chemiluminescence assays (CLA) were used for the blood screening. For each infectious marker, two CLA kits were used, but for each sample, only one kit was used for each infectious marker. An S/CO ≥ 8.0 was considered reactive, and an S/CO
Source: American Journal of Translational Research - Category: Research Authors: Source Type: research
CONCLUSION: Patients with advanced HNSCC and HCC, regardless of viral infection status, could benefit from ICI treatment. Patients with hepatitis B virus-associated HCC were more likely to benefit from ICI treatment than patients without viral infections.REGISTRATION: Our systematic review protocol was registered with the International Prospective Register of Systematic Reviews on March 27, 2020 (registration number CRD42020155326).PMID:34537483 | DOI:10.1016/j.intimp.2021.108128
Source: International Immunopharmacology - Category: Allergy & Immunology Authors: Source Type: research
ConclusionOur findings support a direct association of omega-6 PUFA intake with HCC and an inverse association of MUFA and long-chain omega-3 PUFA intake with HCC.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: RESEARCH ARTICLE Source Type: research
This study was undertaken to investigate the characteristics and survival course of this patient group.METHODS: We retrospectively analyzed the database of patients with HCC at a tertiary center during a 10-year period (2009-2019). All demographic, clinical, laboratory, and tumoral features with survival outcomes were compared between the HCC-CL and HCC-NCL groups.RESULTS: Out of 384 HCC cases, 11.2% (n = 43) had no cirrhosis. The dominant etiology in the HCC-NCL group was hepatitis B virus (n = 26, 60.5%), followed by non-alcoholic fatty liver disease (n = 10, 23.2%), and hepatitis C virus (n = 7, 16.3%). The maximum tumo...
Source: The Turkish Journal of Gastroenterology - Category: Gastroenterology Authors: Source Type: research
In this study, we sought to overcome the limitations of this pyrophosphate bioluminescent assay format by using 2-deoxyadenosine-5-(α-thio)-triphosphate (dATPαS) in place of dATP for PCR amplification, thereby dramatically reducing background signal levels. We leveraged this combination PCR and bioluminescent pyrophosphate assay approach to facilitate HBV detection. This assay yielded a limit of detection of 500 copies/mL, making it more sensitive than traditional bioluminescent assays, about 1000 times more sensitive than that of PCR product analysis by agarose gel electrophoresis, and roughly as sensitive as ...
Source: Applied Biochemistry and Biotechnology - Category: Biochemistry Authors: Source Type: research
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