Togo overcomes ‘sleeping sickness’ as a public health problem

The West African nation of Togo has eliminated human African trypanosomiasis or “sleeping sickness” as a public health problem, becoming the first in the continent to achieve the milestone, the UN World Health Organization (WHO) has said. 
Source: UN News Centre - Health, Poverty, Food Security - Category: International Medicine & Public Health Source Type: news

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ntino de Sousa Trypanosomiases are diseases caused by parasitic protozoan trypanosomes of the genus Trypanosoma. In humans, this includes Chagas disease and African trypanosomiasis. There are few therapeutic options, and there is low efficacy to clinical treatment. Therefore, the search for new drugs for the trypanosomiasis is urgent. This review describes studies of the trypanocidal properties of essential oils, an important group of natural products widely found in several tropical countries. Seventy-seven plants were selected from literature for the trypanocidal activity of their essential oils. The main chemical co...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
The objective set by WHO to reach elimination of human African trypanosomiasis (HAT) as a public health problem by 2020 is being achieved. The next target is the interruption of gambiense-HAT transmission in humans by 2030. To monitor progress towards this target, in areas where specialized local HAT control capacities will disappear, is a major challenge. Test specimens should be easily collectable and safely transportable such as dried blood spots (DBS). Monitoring tests performed in regional reference centres should be reliable, cheap and allow analysis of large numbers of specimens in a high-throughput format. The aim ...
Source: Experimental Parasitology - Category: Parasitology Authors: Tags: Exp Parasitol Source Type: research
Human African Trypanosomiasis &Heart. Expert Rev Cardiovasc Ther. 2020 Sep 23;: Authors: Ortiz HIA, Farina JM, Saldarriaga C, Mendoza I, Sosa Liprandi A, Wyss F, Burgos LM, Alexander B, Baranchuk A Abstract INTRODUCTION: Human African Trypanosomiasis is a neglected tropical disease resulting from the infection with the parasite Trypanosoma brucei. Neurological compromise often dominates, and the impact of cardiovascular involvement has not been fully investigated. Recently, publications indicate that cardiovascular compromise is more frequent than previously thought. Early detection of cardiac comp...
Source: Expert Review of Cardiovascular Therapy - Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research
This study aimed to evaluate if a community-led vector control programme was feasible in the context of DRC’s g-HAT elimination programme. In 2017, a community-led intervention was implemented in three villages in the Kwilu province of DRC. This interventio n was evaluated through an Action Research with qualitative data collected through 21 focus group discussions and 289 hours of observation. Also the geographical location and quality of each Tiny Targets were collected (total number deployed = 2429). This research revealed that community-based appro ach largely worked: people were motivated and proactive, showed a...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Background: Hunting activities play an important role in the survival and subsistence of the population. During hunting activities, trappers go into the bush and end up in the same biotopes with wild animals and flies, vectors of various diseases; they can accidentally get involved in the wild transmission cycle of diseases maintained by vectors and wild animal, potential reservoir hosts. Many researchers reported a tight link between hunting activities and the emergence of some infectious diseases in forest areas.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 0636 Source Type: research
by H élène Clémentine Margareta Baudouin, Laura Pfeiffer, Torsten OchsenreiterTrypanosoma brucei is a single celled eukaryotic parasite and the causative agent of human African trypanosomiasis and nagana in cattle. Aside from its medical relevance,T.brucei has also been key to the discovery of several general biological principles including GPI-anchoring, RNA-editing and trans-splicing. The parasite contains a single mitochondrion with a singular genome. Recent studies have identified several molecular components of the mitochondrial genome segregation machinery (tripartite attachment complex, TAC), wh...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
ConclusionThis description illustrates the complexity of detecting the last HAT cases due to complex diagnosis and the progressive disinterest and unawareness by both health professionals and the population. It confirms the need of implementing passive surveillance in combination with continued sensitization and health staff training.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
[WHO] Brazzaville -- Togo has received validation from the World Health Organization (WHO) for having eliminated human African trypanosomiasis or "sleeping sickness" as a public health problem, becoming the first country in Africa to reach this milestone.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
by Jennifer S. Lord, Rachel S. Lea, Fiona K. Allan, Mechtilda Byamungu, David R. Hall, Jessica Lingley, Furaha Mramba, Edith Paxton, Glyn A. Vale, John W. Hargrove, Liam J. Morrison, Stephen J. Torr, Harriet K. Auty In the absence of national control programmes against Rhodesian human African trypanosomiasis, farmer-led treatment of cattle with pyrethroid-based insecticides may be an effective strategy for foci at the edges of wildlife areas, but there is limited evidence to support this. We combined data on insecticide use by farmers, tsetse abundance and trypanosome prevalence, with mathematical models, to quantify the ...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Abstract Leishmania and Trypanosoma parasites are responsible for the challenging neglected tropical diseases leishmaniases, Chagas disease and Human African Trypanosomiasis, which account for up to 40,000 deaths annually mainly in developing countries. Current chemotherapy relies on drugs with major limits of efficacy and safety, prompting the urgent need of exploring innovative approaches to improve the drug discovery pipeline. The unique trypanothione-based redox pathway, which is absent in the human host, is vital for all trypanosomatids and offers valuable opportunities to guide the rational development of sp...
Source: ChemMedChem - Category: Chemistry Authors: Tags: ChemMedChem Source Type: research
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