Why Airway Gland Secretions Are Abnormally Sticky in Cystic Fibrosis, and Why Not Much Can Be Done About It.
Why Airway Gland Secretions Are Abnormally Sticky in Cystic Fibrosis, and Why Not Much Can Be Done About It.
Dev Cell. 2020 Aug 24;54(4):427-428
Authors: Widdicombe JH
Abstract
In this issue of Developmental Cell, Xie et al. show that in cystic fibrosis, airway gland mucus gels form under conditions of high acidity and protein concentration. This causes them to be unusually stiff. This abnormal rheology cannot be corrected by changing pH or calcium levels in the bathing medium.
PMID: 32841592 [PubMed - in process]
Source: Developmental Cell - Category: Cytology Authors: Widdicombe JH Tags: Dev Cell Source Type: research