Amoxicillin Dosing Regimens for the Treatment of Neonatal Sepsis: Balancing Efficacy and Neurotoxicity.

CONCLUSIONS: The acceptability of regimens is highly influenced by efficacy and toxicity targets, the selection of which is challenging. Novel randomized trial designs combined with pharmacometric modeling and simulation could assist in selecting optimal dosing regimens in this understudied population. PMID: 32841941 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32841941?dopt=Abstract

Source: Neonatology - August 24, 2020 Category: Perinatology & Neonatology Authors: van Donge T, Fuchs A, Leroux S, Pfister M, Rodieux F, Atkinson A, Giannoni E, van den Anker J, Bielicki J Tags: Neonatology Source Type: research