LCM-seq reveals unique transcriptional adaptation mechanisms of resistant neurons and identifies protective pathways in spinal muscular atrophy [RESEARCH]

In conclusion, this in-depth longitudinal transcriptomics analysis in SMA reveals novel cell type–specific changes that, alone and combined, present compelling targets, including Gdf15, for future gene therapy studies aimed toward preserving vulnerable motor neurons.

Source: Genome Research - August 25, 2020 Category: Genetics & Stem Cells Authors: Nichterwitz, S., Nijssen, J., Storvall, H., Schweingruber, C., Comley, L. H., Allodi, I., Lee, M. v. d., Deng, Q., Sandberg, R., Hedlund, E. Tags: RESEARCH Source Type: research