A Challenging Case of Leg Ulcers Associated With Retiform Purpura: Cutaneous Oxalosis in the Setting of Primary Type 1 Hyperoxaluria

Hyperoxaluria, a rare metabolic disorder associated with increased serum oxalate deposits in the skin, kidneys, and other organs, can be primary or secondary.1 Primary hyperoxaluria (PH) types 1 (PH-1) and 2 (PH-2) are autosomal recessive. The most common type, PH-1, results from deficiency of alanine-glyoxylate aminotransferase causing accumulation of glyoxalate and oxalate.1,2 The patient in this report had the most prevalent juvenile form of PH-1, characterized by recurrent calcium oxalate kidney stones preceding development of renal failure.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Medical image Source Type: research