Proteomics Fundamentally Advance the Diagnosis and Management of Amyloidosis
Characterization of the tissue protein deposits is a mainstay in the care of patients with amyloidoses. The precise identification of the amyloid protein is a prerequisite for appropriate therapy, accurate prognosis, and, when indicated, genetic counseling. Over the years, an array of biochemical, histological, and immunological techniques has been used to detect and characterize amyloid fibrils and their constituents, until the advent of proteomics. This methodology combines the abilities to assess the presence of fibrils through the detection of the amyloid proteomic signature, identify the deposited protein, and investigate changes in the tissue proteome induced by the amyloid-formation process.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Francesca Lavatelli, Giampaolo Merlini Tags: Editorial Source Type: research