Downregulation of G3BP2 reduces atherosclerotic lesions in ApoE –/– mice

Atherosclerosis is mainly caused by stress in arterial microenvironments, which results in the formation of stress granules as a consequence of the stress response. As the core protein of stress granules, GTPase-activating protein (SH3 domain)-binding protein 2 (G3BP2) is known to play pivotal roles in tumour initiation, viral infection and Alzheimer ’s disease, but the role of G3BP2 in atherosclerosis development is poorly understood. Previous studies have shown that vaccination with epitopes from self-antigens could reduce atherosclerotic lesions.

Source: Atherosclerosis - August 25, 2020 Category: Cardiology Authors: Tianhan Li, Maharani Safitri, Kang Zhang, Yi Wang, Lu Huang, Yuan Zhu, Richard Daniel, Ling Juan Wu, Juhui Qiu, Guixue Wang Source Type: research