Cancers, Vol. 12, Pages 2423: A Pilot Study on Efficacy of Lipid Bubbles for Theranostics in Dogs with Tumors

Cancers, Vol. 12, Pages 2423: A Pilot Study on Efficacy of Lipid Bubbles for Theranostics in Dogs with Tumors Cancers doi: 10.3390/cancers12092423 Authors: Inoru Yokoe Yusuke Murahata Kazuki Harada Yuji Sunden Daiki Omata Johan Unga Ryo Suzuki Kazuo Maruyama Yoshiharu Okamoto Tomohiro Osaki The combined administration of microbubbles and ultrasound (US) is a promising strategy for theranostics, i.e., a combination of therapeutics and diagnostics. Lipid bubbles (LBs), which are experimental theranostic microbubbles, have demonstrated efficacy in vitro and in vivo for both contrast imaging and drug delivery in combination with US irradiation. To evaluate the clinical efficacy of LBs in combination with US in large animals, we performed a series of experiments, including clinical studies in dogs. First, contrast-enhanced ultrasonography using LBs (LB-CEUS) was performed on the livers of six healthy Beagles. The hepatic portal vein and liver tissue were enhanced; no adverse reactions were observed. Second, LB-CEUS was applied clinically to 21 dogs with focal liver lesions. The sensitivity and specificity were 100.0% and 83.3%, respectively. These results suggested that LB-CEUS could be used safely for diagnosis, with high accuracy. Finally, LBs were administered in combination with therapeutic US to three dogs with an anatomically unresectable solid tumor in the perianal and cervical region to determine the enhancement of the chemotherapeutic effect of l...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research