Endocrine and Metabolic Insights from Pancreatic Surgery.

Endocrine and Metabolic Insights from Pancreatic Surgery.
Trends Endocrinol Metab. 2020 Aug 20;:
Authors: Mezza T, Cefalo CMA, Cinti F, Quero G, Pontecorvi A, Alfieri S, Holst JJ, Giaccari A
Abstract
Although it is well established that diabetes can also develop as a result of diseases or maneuvers on the exocrine pancreas, the complex relationship between glucose disorders and underlying pancreatic disease is still debated. There is evidence that several features linked to pancreatic diseases can modify endocrine and metabolic conditions before and after surgery. However, pancreatic surgery provides a rare opportunity to correlate in vivo endocrine and metabolic pathways with ex vivo pancreatic samples, to examine the endocrine and metabolic effects of acute islet removal, and finally to clarify the pathogenesis of diabetes. This approach could therefore represent a unique method to shed light on the molecular mechanisms, predicting factors, and metabolic consequences of insulin resistance, islet plasticity, β cell failure, and type 2 diabetes.
PMID: 32830029 [PubMed - as supplied by publisher]

Source: Trends in Endocrinology and Metabolism: TEM - August 19, 2020 Category: Endocrinology Authors: Mezza T, Cefalo CMA, Cinti F, Quero G, Pontecorvi A, Alfieri S, Holst JJ, Giaccari A Tags: Trends Endocrinol Metab Source Type: research