Clinical Implementation of Prolonged Liver Preservation and Monitoring Through Normothermic Machine Perfusion in Liver Transplantation

Conclusions. NMP in a multidisciplinary approach enables a safe prolongation of liver preservation and overnight organ care. A first field test of NMP indicates safety and benefit of this approach.
Source: Transplantation - Category: Transplant Surgery Tags: Original Clinical Science—Liver Source Type: research

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In this study, we intravenously administrated the young mitochondria into aged mice to evaluate whether energy production increase in aged tissues or age-related behaviors improved after the mitochondrial transplantation. The results showed that heterozygous mitochondrial DNA of both aged and young mouse coexisted in tissues of aged mice after mitochondrial administration, and meanwhile, ATP content in tissues increased while reactive oxygen species (ROS) level reduced. Besides, the mitotherapy significantly improved cognitive and motor performance of aged mice. Our study, at the first report in aged animals, not only prov...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusion The impact of sepsis on the gut is manifold, e.g., sepsis mediated alteration of the gut-blood barrier and increase in the intestinal permeability, which may correlate with the phenomena of bacterial translocation and lymphatic activation (“toxic-lymph”). Systemic consequences of sepsis are widespread and concern to the coagulative system, the microbiome as well as enzymes, such as pancreatic proteases, MMPs and IAPs. Nevertheless, the therapeutic approaches for modulating the mucosal immune system are still rarely effective in daily routine. Recent published studies showing that treatment with FMT,...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Abstract One of the most prominent results of our age is organ transplantation, the single treatment option for patients with end-stage organ failure. The success of transplants depends on the donor care, the patient preoperative preassessment, the perioperative care of organ transplantation and aftercare. Successful transplantation therefore requires a prominent level of continuous collaboration between the surgeon, anaesthesiologist, radiologist, internal medicine and hepatologist, laboratory physician and almost all their associates. The complex interdisciplinary approach based on the research results can be us...
Source: Orvosi Hetilap - Category: General Medicine Authors: Tags: Orv Hetil Source Type: research
AbstractPurpose of ReviewWe will present some relevant concepts on the preoperative evaluation of patients with end-stage liver disease and describe some new intraoperative management strategies for liver transplantation. This review is limited to three topics: cardiac issues, pulmonary issues, and coagulation issues.Recent FindingsWhile dobutamine stress echocardiography and myocardial perfusion scintigraphy are the most common screening methods for coronary artery disease, computed tomography techniques are gaining popularity although their value is still unclear. Positive screening tests should be followed by coronary a...
Source: Current Anesthesiology Reports - Category: Anesthesiology Source Type: research
NEAR INFRARED SPECTROSCOPY (NIRS) is a noninvasive continuous monitor of the balance between tissue oxygen delivery and consumption.1,2 NIRS reflects real-time changes in the microcirculatory tissue perfusion, and as such, allows for rapid feedback on tissue perfusion for a patient who otherwise may appear adequately resuscitated from a macrohemodynamic perspective.3 –5 NIRS is a nonspecific diagnostic tool that must be interpreted within the appropriate clinical context. Abnormal values merely suggest a problem may exist; it is incumbent upon the clinician to interpret the data to make a diagnosis and an intervention.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Editorial Source Type: research
Authors: Sørensen H Abstract Likely, maintained organ and notably cerebral perfusion, secures rapid recovery following anesthesia. To secure cerebral blood flow (CBF) at least mean arterial pressure (MAP) and the arterial carbon dioxide tension (PaCO2) need to be considered. CBF is "autoregulated", i.e. stays more or less stable within a MAP of 50-150 mmHg, but the lower limit appears to depend on the central blood volume and/or cardiac output, illustrated by a decrease in CBF at a MAP of 80 mmHg with a compromised central blood volume, while CBF remains constant with a MAP
Source: Danish Medical Journal - Category: Journals (General) Tags: Dan Med J Source Type: research
Conclusions: Human adipose-derived stromal cells improved survival and mesenteric perfusion and attenuated the mucosal damage associated with intestinal I/R injury. hASCs should be considered as a plausible cell source for novel cellular treatment plans following intestinal ischemia.
Source: Shock - Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research
CONCLUSIONS: The management of antifungal prophylaxis in solid organ transplant recipients requires the application of knowledge and skills that are detailed in our recommendations and the algorithm developed therein. These recommendations, based on the DELPHI methodology, may help to identify potential patients, standardize their management and improve overall prognosis. PMID: 27067875 [PubMed - as supplied by publisher]
Source: Revista Iberoamericana de Micologia - Category: Biology Authors: Tags: Rev Iberoam Micol Source Type: research
Conclusion Hepatic artery thrombosis varies in its clinical presentation, but it usually requires early and aggressive management.
Source: Colombian Journal of Anesthesiology - Category: Anesthesiology Source Type: research
Conclusions Isoflurane does not protect from brain death-associated aggravation of cold hepatic ischemia-reperfusion injury. PMID: 25598073 [PubMed - in process]
Source: Annals of Transplantation - Category: Transplant Surgery Authors: Tags: Ann Transplant Source Type: research
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