Altered levels of salivary and plasma pain related markers in temporomandibular disorders

ConclusionThe higher levels of salivary and plasma glutamate in patients with TMD-myalgia compared to controls strengthens its importance in the pathophysiology of TMD-myalgia. However, the lack of correlation to pain levels question its role as a putative biomarker. Patients with TMD-myalgia further had lower levels of salivary NGF and BDNF, but higher plasma BDNF. These results and their correlations to psychological distress warrant further investigations.
Source: The Journal of Headache and Pain - Category: Neurology Source Type: research