Association of Mps one binder kinase activator 1 (MOB1) expression with poor disease ‐free survival in individuals with non‐small cell lung cancer

ConclusionsOur results suggest that MOB1 might promote early recurrence of NSCLC by increasing vascular invasion by tumor cells.Key pointsSignificant findings of the studyWe found that high MOB1 expression in surgical specimens of lung adenocarcinoma was associated with poor disease ‐free survival and with intratumoral vascular invasion. MOB1 expression also promoted the invasiveness of NSCLC cells in vitro.What this study addsOur results thus suggest that high MOB1 expression is a risk factor for early postoperative recurrence in lung adenocarcinoma.

Source: Thoracic Cancer - August 24, 2020 Category: Cancer & Oncology Authors: Nobuhisa Ando, Kentaro Tanaka, Kohei Otsubo, Gouji Toyokawa, Yuki Ikematsu, Maako Ide, Yasuto Yoneshima, Eiji Iwama, Hiroyuki Inoue, Kayo Ijichi, Tetsuzo Tagawa, Yoichi Nakanishi, Isamu Okamoto Tags: ORIGINAL ARTICLE Source Type: research