Molecular Docking analysis of the TNIK Receptor protein with a potential Inhibitor from the NPACT databas.

Molecular Docking analysis of the TNIK Receptor protein with a potential Inhibitor from the NPACT databas. Bioinformation. 2020;16(5):387-392 Authors: Rosita AS, Begum TN Abstract It is of interest to design and develop efficient inhibitors to the TNIK protein target in Wnt signaling pathways in the context of colorectal cancer (CRC) using molecular docking models. We show data to support that a compound named aglafoline (methyl (1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H cyclopenta [b] [1] from the NPACT (Naturally Occurring Plant-based Anti-cancer Compound-Activity-Target database) database have optimal binding features with the TNIK receptor for further consideration in this context. PMID: 32831519 [PubMed - as supplied by publisher]
Source: Bioinformation - Category: Bioinformatics Authors: Tags: Bioinformation Source Type: research