DO-HEALTH: Vitamin D3 - Omega3 - Home exercise - Healthy aging and longevity trial - Design of a multinational clinical trial on healthy aging among European seniors

DO-HEALTH is a multi-center clinical trial among 2157 community-dwelling European men and women age 70 and older. The 2x2x2 randomized-control factorial design trial tested the individual and additive benefit, as well as the cost-effectiveness, of 3 interventions: vitamin D 2000  IU/day, omega-3 fatty acids 1000 mg/day (EPA + DHA, ratio 1:2), and a 30-minute 3 times/week home exercise (strength versus flexibility). Each treatment tested has shown considerable prior promise from mechanistic studies, small clinical trials, or large cohort studies, in the prevention of common age-related chronic diseases, but definitive data are missing.

Source: Contemporary Clinical Trials - August 24, 2020 Category: Radiology Authors: Heike A. Bischoff-Ferrari, Caroline de Godoi Rezende Costa Molino, Sandrine Rival, Bruno Vellas, Ren é Rizzoli, Reto W. Kressig, John A. Kanis, JoAnn E. Manson, Bess Dawson-Hughes, Endel J. Orav, José A.P. da Silva, Michael Blauth, Dieter Felsenberg, St Source Type: research