Impaired Renal Hemodynamics and Glomerular Hyperfiltration Contribute to Hypertension-Induced Renal Injury.

Impaired Renal Hemodynamics and Glomerular Hyperfiltration Contribute to Hypertension-Induced Renal Injury. Am J Physiol Renal Physiol. 2020 Aug 24;: Authors: Fan L, Gao W, Nguyen BV, Jefferson JR, Liu Y, Fan F, Roman RJ Abstract Recently, we reported a mutation in γ-Adducin (ADD3) was associated with an impaired myogenic response of the afferent arteriole and hypertension-induced chronic kidney disease (CKD) in FHH rats. However, the mechanisms by which altered renal blood flow (RBF) autoregulation promotes hypertension-induced renal injury remains to be determined. The present study compared the time course of changes in renal hemodynamics and the progression of CKD during the development of DOCA-salt hypertension in FHH 1BN congenic rats (WT) with an intact myogenic response versus FHH 1BN Add3KO (Add3KO) rats which have impaired myogenic response. RBF was well autoregulated in WT rats but not in Add3KO rats. Glomerular capillary pressure (Pgc) rose by 6 versus 14 mmHg in WT versus Add3KO rats when blood pressure increased from 100 to 150 mmHg. After one week of hypertension, glomerular filtration rate (GFR) increased by 38%, and the glomerular nephrin expression decreased by 20% in Add3KO rats. Neither were altered in WT rats. Proteinuria doubled in WT rats versus a six-fold increase in Add3KO rats. The degree of renal injury was greater in Add3KO rats than WT rats after three weeks of hypertension. RBF, GFR, Pgc were lower by 2...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research