Is dna repair a potential target for effective therapies against malignant mesothelioma?

The pathogenic mechanisms of malignant pleural mesothelioma (MPM) are related to exposure of the mesothelial cells to asbestos fibres, which directly interfere with mitotic spindle formation and induce chronic inflammation with consequent oxidative stress and DNA damage. The incidence of MPM in Europe is increasing due to the long latency and persistent environmental exposure to asbestos and other mineral fibres [1]. Prognosis is dismal, with a short median survival after diagnosis (9-12 months in untreated patients).
Source: Cancer Treatment Reviews - Category: Cancer & Oncology Authors: Tags: Anti-tumour Treatment Source Type: research