Thrombolysis during CPR

Editor – Hamera et al. reported the successful cardiopulmonary resuscitation (CPR) of a 47-year-old patient with out-of-hospital cardiac arrest (OHCA) after administration of intravenous tissue plasminogen activator (t-PA) [1]. This well written case report relights the topic on systemic thrombolysis dur ing CPR. Thrombolytics may rapidly induce reduction of plasma viscosity by cleavage of fibrinogen [2]. Under the restricted conditions of ongoing CPR thrombolysis enhances microcirculation, improves coronary perfusion and most notably ameliorates cerebral reperfusion [3].
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research