Efficacy of the eribulin, pertuzumab, and trastuzumab combination therapy for human epidermal growth factor receptor 2 –positive advanced or metastatic breast cancer: a multicenter, single arm, phase II study (JBCRG-M03 study)

Conclusions In patients with HER2-positive AMBC, eribulin, pertuzumab, and trastuzumab combination therapy exhibited substantial antitumor activity with an acceptable safety profile. Hence, we have started a randomized phase III study comparing eribulin and a taxane in combination with pertuzumab and trastuzumab for the treatment of HER2-positive AMBC.Trial registration ID: UMIN-CTR: UMIN000012232.
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research