Food protein-induced allergic proctocolitis may have distinct phenotypes

Background: Food protein-induced allergic proctocolitis (FPIAP) is a nonimmunoglobulin E (IgE)-mediated food allergy, which presents with bloody mucoid stool in infants.Objective: Although IgE-mediated allergy and sensitizations to offending foods have been described in other non-IgE-mediated food allergies, it has not been investigated in FPIAP. Therefore, we aimed to investigate IgE-mediated allergy and sensitization to offending foods in FPIAP.Methods: Patients (n=204) were retrospectively recruited and grouped as FPIAP (n=180; FPIAP+/-symptoms of IgE-mediated food hypersensitivity to offending and non-offending foods at initial consultation), FPIAP-IgE sensitization to offending foods (n=17), and FPIAP-transition to IgE-mediated allergy to offending foods (n=7).

Source: Annals of Allergy, Asthma and Immunology - August 23, 2020 Category: Allergy & Immunology Authors: P ınar Gur Cetinkaya, Melike Kahveci, Umit Murat Sahiner, Bulent Enis Sekerel, Ozge Soyer Tags: Original Article Source Type: research