Integrative Genomics for the Interpretation of Genetic Loci Implicated in Neurodevelopmental Disorders

Our understanding of neuropsychiatric disorders has gained tremendous progress with the advancement of genetics studies, both in establishing the high heritability for these classes of disorders and through the identification of specific genetic associations (1). Large-scale genetic studies —both rare-variant, family-based studies and common variant, genome-wide association studies (GWASs)—have uncovered the genetic architecture of neuropsychiatric disease and implicate common variants as the largest contributor to disease liability for the majority of these disorders, including au tism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), schizophrenia, and bipolar disorder (2).
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research