The antiviral activities of TRIM proteins.

The antiviral activities of TRIM proteins.
Curr Opin Microbiol. 2020 Aug 20;59:50-57
Authors: Koepke L, Gack MU, Sparrer KM
Abstract
Tripartite motif (TRIM) proteins are a highly versatile family of host-cell factors that play an integral role in the mammalian defense against pathogens. TRIM proteins regulate either transcription-dependent antiviral responses such as pro-inflammatory cytokine induction, or they modulate other important cell-intrinsic defense pathways like autophagy. Additionally, TRIM proteins exert direct antiviral activity whereby they antagonize specific viral components through diverse mechanisms. Here, we summarize the latest discoveries on the molecular mechanisms of antiviral TRIM proteins and also discuss current and future trends in this fast-evolving field.
PMID: 32829025 [PubMed - as supplied by publisher]

Source: Current Opinion in Microbiology - August 19, 2020 Category: Microbiology Authors: Koepke L, Gack MU, Sparrer KM Tags: Curr Opin Microbiol Source Type: research